#LOCATIONS OF COLOL HOW TO#
#LOCATIONS OF COLOL TRIAL#

(See the table below.) Median Overall Survival by Tumor Location and Therapy And patients with right-sided tumors had better outcomes when treated with bevacizumab.

(Patients whose tumors have wild-type KRAS are more likely to respond to cetuximab than patients whose tumors have mutations in KRAS, who don’t respond at all to the therapy.)Īlthough patients whose tumors originated in the left colon lived substantially longer after treatment than patients whose tumors originated in the right colon, the survival improvement for patients treated with cetuximab was more pronounced.

#LOCATIONS OF COLOL TRIAL#

The researchers focused their analysis on the 971 patients in the trial whose tumors had the wild-type, or normal, form of the KRAS gene. The more than 44,000 biological samples collected in the CALGB/SWOG 80405 trial (from tumors and normal tissue), provided an ideal resource to further investigate differences between left- and right-sided colorectal cancers, Dr. But uncertainty about its influence remained, he added, “because of the nature of the studies and small numbers.” Several previous studies had suggested, however, that tumor location in the colon may be an important clinical and biological consideration, Dr. Results from the trial, presented in 2014, showed no difference in overall or progression-free survival between the treatment groups. In CALGB/SWOG 80405, the clinical trial on which this retrospective analysis was based, patients were randomly assigned to primary treatment with either cetuximab or bevacizumab in combination with one of two commonly used chemotherapy regimens ( FOLFIRI or FOLFOX). Venook and his colleagues reported their study findings at a May 18 American Society for Clinical Oncology (ASCO) press briefing in advance of their presentation early next month at the ASCO annual meeting in Chicago. Other investigators, however, caution that further confirmation is needed from prospective studies that provide more information about the underlying biology that may account for the observed survival differences.ĭr.

The findings support the idea that “colorectal cancers that originate on the right side should be treated differently than colon cancers originating on the left,” said the study’s lead investigator, Alan Venook, M.D., of the University of California, San Francisco. Patients with left-sided primary tumors are more likely to benefit from the targeted therapy cetuximab (Erbitux®), the study suggests, whereas patients whose tumors originated in the right colon may be better off receiving bevacizumab (Avastin®). The study also linked tumor location to the likelihood of benefit from specific targeted therapies used to treat patients with colorectal cancer. The study-a retrospective analysis of data from a large NCI-funded phase III clinical trial-found that patients whose cancer originated in the left side of the colon (distal colon) lived more than a year longer after initial treatment than patients whose disease originated in the right side of the colon (proximal colon). In patients with metastatic colorectal cancer, the location in the colon where the tumor originated appears to strongly influence how long patients live, according to a new study. Saving Earth Britannica Presents Earth’s To-Do List for the 21st Century.Credit: National Cancer Institute / Terese Winslow.Britannica Beyond We’ve created a new place where questions are at the center of learning.100 Women Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians.

#LOCATIONS OF COLOL HOW TO#

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Locations of colol